Hepatoprotective activity of 95% ethanolic extract of roots of Pisonia grandis R.Br. was studied against paracetamol induced hepatic injury in wister rats. In addition, anti-inflammatory activity was studied by in vitro models. Pre-treatment with 95% ethanolic extract (P.G.) reduced the biochemical markers of hepatic injury like serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, alkaline phosphatase, bilirubin, cholesterol, and tissue glutathione (GSH) levels. Histopathological observations also revealed that pretreatment with P.G. protected the animals from paracetamol induced liver damage. Similarly the ethanolic extract of P.G. was evaluated for anti-inflammatory activity in rats at dose level of 250mg/kg in carrageenin induced paw oedema mercury displacement method. The ethanolic extract showed significant reduction in paw oedema as less compared to standard drug i.e.Indomethacin.
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